General Information

  • ID:  hor000008
  • Uniprot ID:  P84220
  • Protein name:  hypertrehalosemic neuropeptide
  • Gene name:  NA
  • Organism:  Blattella germanica (German cockroach) (Blatta germanica)
  • Family:  AKH/HRTH/RPCH family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Blattella (genus), Blattellinae (subfamily), Ectobiidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  VNFSPGWGT
  • Length:  9
  • Propeptide:  QVNFSPGWGT
  • Signal peptide:  NA
  • Modification:  T9 Threonine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May be involved in regulation of metabolic homoeostasis;make available acetylCoA, from triacylglycerols, for synthesis of proline in the fatbody
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000008_AF2.pdbhor000008_ESM.pdb

Physical Information

Mass: 110691 Formula: C45H61N11O13
Absent amino acids: ACDEHIKLMQRY Common amino acids: G
pI: 6.11 Basic residues: 0
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -14.44 Boman Index: -138
Half-Life: 100 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 32.22
Instability Index: 3376.67 Extinction Coefficient cystines: 5500
Absorbance 280nm: 687.5

Literature

  • PubMed ID:  2080017
  • Title:  Structure of the Hypertrehalosemic Neuropeptide of the German Cockroach, Blattella Germanica